Papers
Documents
Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment
| Filesize: | 1.27 MB |
Escribá PV, Busquets X, Inokuchi JI, Balogh G, Török Z, Horváth I, Harwood JL, Vígh L.
Prog Lipid Res. 2015 May 9;59:38-53. Review.
Oral 2-hydroxyoleic acid inhibits reflex hypersensitivity and open-field-induced anxiety after spared nerve injury
| Filesize: | 588.54 kB |
G. Avila-Martin, I. Galan-Arriero, A. Ferrer-Donato, X. Busquets, J. Gomez-Soriano, P.V. Escribá, J. Taylor.
Eur J Pain. 2015 Jan;19(1):111-22.
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease
| Filesize: | 1.18 MB |
Torres M, Price SL, Fiol-Deroque MA, Marcilla-Etxenike A, Ahyayauch H, Barceló-Coblijn G, Terés S, Katsouri L, Ordinas M, López DJ, Ibarguren M, Goñi FM, Busquets X, Vitorica J, Sastre M, Escribá PV.
Biochim Biophys Acta. 2014 Jun;1838(6):1680-92
The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health
| Filesize: | 1009.59 kB |
Ibarguren M, López DJ, Escribá PV.
Biochim Biophys Acta. 2014 Jun;1838(6):1518-28
Regulation of the cancer cell membrane lipid composition by NaCHOleate: effects on cell signaling and therapeutical relevance in glioma
| Filesize: | 1 MB |
Lladó V, López DJ, Ibarguren M, Alonso M, Soriano JB, Escribá PV, Busquets X.
Biochim Biophys Acta. 2014 Jun;1838(6):1619-27
Membrane structure and function: relevance of lipid and protein structures in cellular physiology, pathology and therapy
| Filesize: | 185.01 kB |
Escribá PV, Nicolson GL.
Biochim Biophys Acta. 2014 Jun;1838(6):1449-50.
Changes in membrane organization upon spontaneous insertion of 2-hydroxylated unsaturated fatty acids in the lipid bilayer
| Filesize: | 2.23 MB |
Khmelinskaia A, Ibarguren M, de Almeida RF, López DJ, Paixão VA, Ahyayauch H, Goñi FM, Escribá PV.
Langmuir. 2014 Mar 4;30(8):2117-28
Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer’s disease following 2-hydroxy-DHA treatment
| Filesize: | 742.35 kB |
Fiol-deRoque MA, Gutierrez-Lanza R, Terés S, Torres M, Barceló P, Rial RV, Verkhratsky A, Escribá PV, Busquets X, Rodríguez JJ.
Biogerontology. 2013 Dec;14(6):763-75
2-Hydroxy Arachidonic Acid: A New Non-Steroidal Anti-Inflammatory Drug
| Filesize: | 3.8 MB |
Lopez DH, Fiol-deRoque MA, Noguera-Salvà MA, Terés S, Campana F, Piotto S, Castro JA, Mohaibes RJ, Escribá PV, Busquets X.
PLoS One. 2013 Aug 27;8(8):e72052
Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells
| Filesize: | 1.03 MB |
Martin ML, Liebisch G, Lehneis S, Schmitz G, Alonso-Sande M, Bestard-Escalas J, Lopez DH, García-Verdugo JM, Soriano-Navarro M, Busquets X, Escribá PV, Barceló-Coblijn G.
J Lipid Res. 2013 May;54(5):1457-65.
The role of membrane fatty acid remodeling in the antitumor mechanism of action of 2-hydroxyoleic acid
| Filesize: | 1.99 MB |
Martin ML, Barceló-Coblijn G, de Almeida RF, Noguera-Salvà MA, Terés S, Higuera M, Liebisch G, Schmitz G, Busquets X, Escribá PV.
Biochim Biophys Acta. 2013 May;1828(5):1405-13
2OHOA Induces ER Stress and Autophagy in Various Human Glioma Cell Lines
| Filesize: | 2.2 MB |
Marcilla-Etxenike A, Martín ML, Noguera-Salvà MA, García-Verdugo JM, Soriano-Navarro M, Dey I, Escribá PV, Busquets X.
PLoS One. 2012;7(10):e48235
Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells
| Filesize: | 265.01 kB |
Terés S, Lladó V, Higuera M, Barceló-Coblijn G, Martin ML, Noguera-Salvà MA, Marcilla-Etxenike A, García-Verdugo JM, Soriano-Navarro M, Saus C, Gómez-Pinedo U, Busquets X, Escribá PV.
Autophagy. 2012 Oct;8(10):1542-4.
2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy
| Filesize: | 3.03 MB |
Terés S, Lladó V, Higuera M, Barceló-Coblijn G, Martin ML, Noguera-Salvà MA, Marcilla-Etxenike A, García-Verdugo JM, Soriano-Navarro M, Saus C, Gómez-Pinedo U, Busquets X, Escribá PV.
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8489-94
Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells
| Filesize: | 1.31 MB |
Barceló-Coblijn G, Martin ML, de Almeida RF, Noguera-Salvà MA, Marcilla-Etxenike A, Guardiola-Serrano F, Lüth A, Kleuser B, Halver JE, Escribá PV.
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19569-74.
Interactions of fatty acids with DEPE membranes: X-ray diffraction and molecular dynamics studies
| Filesize: | 1.25 MB |
Cordomí A, Prades J, Frau J, Vögler O, Funari SS, Perez JJ, Escribá PV, Barceló F.
J Lipid Res. 2010 May;51(5):1113-24.
2OHOA induces apoptosis in Jurkat and other cancer cells
| Filesize: | 1.09 MB |
Llado V, Gutierrez A, Martínez J, Casas J, Terés S, Higuera M, Galmés A, Saus C, Besalduch J, Busquets X, Escribá PV.
J Cell Mol Med. 2010 Mar;14(3):659-70
Pivotal role of DHFR knockdown in the anticancer activity of 2-hydroxyoleic acid
| Filesize: | 1.11 MB |
Lladó V, Terés S, Higuera M, Alvarez R, Noguera-Salva MA, Halver JE, Escribá PV, Busquets X.
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13754-8.
Membrane Lipid Therapy
| Filesize: | 270.1 kB |
Encyclopedia of Cancer, M. Schwabb Ed.
Springer 2nd edition, 2008
Oleic acid content is responsible for the reduction in blood pressure induced by olive oil
| Filesize: | 613.83 kB |
Terés S, Barceló-Coblijn G, Benet M, Alvarez R, Bressani R, Halver JE, Escribá PV.
Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13811-6
Membranes: a meeting point for lipids, proteins and therapies
| Filesize: | 675.48 kB |
Escribá PV, González-Ros JM, Goñi FM, Kinnunen PK, Vigh L, Sánchez-Magraner L, Fernández AM, Busquets X, Horváth I, Barceló-Coblijn G.
J Cell Mol Med. 2008 Jun;12(3):829-75.
Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats
| Filesize: | 198.39 kB |
Vögler O, López-Bellan A, Alemany R, Tofé S, González M, Quevedo J, Pereg V, Barceló F, Escriba PV.
Int J Obes (Lond). 2008 Mar;32(3):464-73
Interaction of the C-Terminal Region of the Gg Protein with Model Membranes
| Filesize: | 478.91 kB |
Barceló F, Prades J, Encinar JA, Funari SS, Vögler O, González-Ros JM, Escribá PV.
Biophys J. 2007 Oct 1;93(7):2530-41
Synthesis and mass spectroscopy kinetics of a novel ternary copper complex with cytotoxic activity
| Filesize: | 525.54 kB |
Barceló-Oliver M, García-Raso A, Terrón A, Molins E, Prieto MJ, Moreno V, Martínez J, Lladó V, López I, Gutiérrez A, Escribá PV.
J Inorg Biochem. 2007 Apr;101(4):649-59.
Membrane Lipid Therapy: a new approach in molecular medicine
| Filesize: | 2.86 MB |
Escribá PV.
Trends Mol Med. 2006 Jan;12(1):34-43
The Repression of E2F-1 Is Critical for the Activity of 2OHOA against Cancer
| Filesize: | 397.05 kB |
Martínez J, Gutiérrez A, Casas J, Lladó V, López-Bellan A, Besalduch J, Dopazo A, Escribá PV.
J Pharmacol Exp Ther. 2005 Oct;315(1):466-74.
Membrane Structure Modulation, PKC Activation and Anticancer Activity of Minerval
| Filesize: | 428.47 kB |
Martínez J, Vögler O, Casas J, Barceló F, Alemany R, Prades J, Nagy T, Baamonde C, Kasprzyk PG, Terés S, Saus C, Escribá PV.
Mol Pharmacol. 2005 Feb;67(2):531-40
The Gbg dimer drives the interaction of heterotrimeric Gi proteins with nonlamellar membrane struc.
| Filesize: | 232.78 kB |
Vögler O, Casas J, Capó D, Nagy T, Borchert G, Martorell G, Escribá PV.
J Biol Chem. 2004 Aug 27;279(35):36540-5.
The hypotensive drug 2-hydroxyoleic acid modifies the structural properties of model membranes
| Filesize: | 647.21 kB |
Barceló F, Prades J, Funari SS, Frau J, Alemany R, Escribá PV.
Mol Membr Biol. 2004 Jul-Aug;21(4):261-8.