Membrane Lipid Therapy, a ground breaking innovation

Membrane Lipid Therapy (MLT) is an innovative scientific platform based on an expanding area of knowledge in today’s cell biology. The most commonly used rational approach in drug design involves isolating a protein to elucidate its structure and then the design of molecules (chemicals, antibodies…) that regulate its activity. In MLT the molecules designed to interact and inhibit the activity of such membrane-associated signal transduction proliferative proteins targets are actually synthetic fatty acids.


This novel therapeutic approach (MLT) constitutes a "disruptive innovation" that can lead to the development of transformative new medicines with an exceptional safety/efficacy combination in serious pathologies with critical medical needs unmet, such as Oncology, Neurodegenerative diseases, Metabolic disorders or Inflammation.


The potential translation of significant clinical benefit to patients of MLT-based products is being evaluated in different studies, such as MIN-001-1203, the first clinical trial with 2-OHOA in patients with advanced solid tumours, including malignant glioma, which has already been completed with very promising results.

Relevant related documents:

icon Membrane-lipid therapy: A historical perspective of membrane-targeted therapies - From lipid bilayer structure to the pathophysiological regulation of cells. (924.16 kB) Biochim Biophys Acta. 2017 Sep;1859(9 Pt B):1493-1506.

icon Changes in membrane organization upon spontaneous insertion of 2-hydroxylated unsaturated fatty acids in the lipid bilayer (2.23 MB). Langmuir. 2014 Mar 4;30(8):2117-28

icon Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment (1.27 MB). Prog Lipid Res. 2015 May 9;59:38-53. Review.

icon The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health (1009.59 kB). Biochim Biophys Acta. Jun. 2014

icon Membrane structure and function: relevance of lipid and protein structures in cellular physiology, pathology and therapy (185.01 kB). Biochim Biophys Acta. Jun. 2014

icon Membrane Lipid Therapy: a new approach in molecular medicine (2.86 MB). Trends in Molecular Medicine, Jan. 2006

icon Membranes: a meeting point for lipids, proteins and therapies (675.48 kB). J. Cellular and Molecular Medicine, 2008

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