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pdf Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity

Massalha W, et al. Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity. Biosci Rep. 2019 Jan 18;39(1). pii: BSR20181661. doi: 10.1042/BSR20181661

pdf The Opposing Contribution of SMS1 and SMS2 to Glioma Progression and Their Value in the Therapeutic Response to 2OHOA

Paula Fernández-García, Catalina A. Rosselló, Raquel Rodríguez-Lorca, Roberto Beteta-Göbel, Javier Fernández-Díaz, Victoria Lladó, Xavier Busquets and Pablo V. Escribá. Cancers 2019, 11, 88

pdf A role for lipids as agents to alleviate stroke damage: the neuroprotective effect of 2-hydroxy arachidonic acid

Ugidos IF et al. A role for lipids as agents to alleviate stroke damage: the neuroprotective effect of 2-hydroxy arachidonic acid. Neural Regen Res. 2017 Aug;12(8):1273-1275. doi: 10.4103

pdf Neuroprotective effect of 2-hydroxy arachidonic acid in a rat model of transient middle cerebral artery occlusion

Ugidos IF et al. Neuroprotective effect of 2-hydroxy arachidonic acid in a rat model of transient middle cerebral artery occlusion. Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt B):1648-1656. doi: 10.1016

pdf The hydroxylated form of docosahexaenoic acid (DHA-H) modifies the brain lipid composition in a model of Alzheimer's disease, improving behavioral motor function and survival

Mohaibes RJ, et al. The hydroxylated form of docosahexaenoic acid (DHA-H) modifies the brain lipid composition in a model of Alzheimer's disease, improving behavioral motor function and survival. Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt B):1596-1603. doi: 10.1016

pdf G protein-membrane interactions II: Effect of G protein-linked lipids on membrane structure and G protein-membrane interactions

Casas J et al. G protein-membrane interactions II: Effect of G protein-linked lipids on membrane structure and G protein-membrane interactions. Biochim Biophys Acta. 2017 Sep;1859(9 Pt B):1526-1535.

pdf G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization

Álvarez R et al. G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization. Biochim Biophys Acta. 2015 Nov;1851(11):1511-20

pdf Brain Lipids in the Pathophysiology and Treatment of Alzheimer’s Disease Popular

Manuel Torres et al. (2016). Update on Dementia. Chapter 7.  Dr. Davide Moretti (Ed.) Brain Lipids in the Pathophysiology and Treatment of Alzheimer’s Disease. InTech, DOI: 10.5772/64757

pdf Membrane-lipid therapy: A historical perspective of membrane-targeted therapies - From lipid bilayer structure to the pathophysiological regulation of cells

Escriba PV. Membrane-lipid therapy: A historical perspective of membrane-targeted therapies - From lipid bilayer structure to the pathophysiological regulation of cells. Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt B):1493-1506. doi: 10.1016

pdf Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment Popular

Escribá PV, Busquets X, Inokuchi JI, Balogh G, Török Z, Horváth I, Harwood JL, Vígh L. Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment. Prog Lipid Res. 2015 May 9;59:38-53. Review.

pdf The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer’s disease Popular

Torres M, Marcilla-Etxenike A, Fiol-deRoque MA, Escribá PV, Busquets X.
Apoptosis. 2015 May; 20(5):712-24

pdf Oral 2-hydroxyoleic acid inhibits reflex hypersensitivity and open-field-induced anxiety after spared nerve injury Popular

G. Avila-Martin, I. Galan-Arriero, A. Ferrer-Donato, X. Busquets, J. Gomez-Soriano, P.V. Escribá, J. Taylor. Oral 2-hydroxyoleic acid inhibits reflex hypersensitivity and open-field-induced anxiety after spared nerve injury. Eur J Pain. 2015 Jan;19(1):111-22.

pdf Analysis of the lipidome of xenografts using MALDI-IMS and UHPLC-ESI-QTOF

Fernández R, Lage S, Abad-García B, Barceló-Coblijn G, Terés S, López DH, Guardiola-Serrano F, Martín ML, Escribá PV, Fernández JA. Analysis of the lipidome of xenografts using MALDI-IMS and UHPLC-ESI-QTOF. J Am Soc Mass Spectrom. 2014 Jul;25(7):1237-46

pdf Membrane structure and function: relevance of lipid and protein structures in cellular physiology, pathology and therapy Popular

Escribá PV, Nicolson GL. Membrane structure and function: relevance of lipid and protein structures in cellular physiology, pathology and therapy. Biochim Biophys Acta. 2014 Jun;1838(6):1449-50.

pdf Regulation of the cancer cell membrane lipid composition by NaCHOleate: effects on cell signaling and therapeutical relevance in glioma Popular

Lladó V, López DJ, Ibarguren M, Alonso M, Soriano JB, Escribá PV, Busquets X. Regulation of the cancer cell membrane lipid composition by NaCHOleate: effects on cell signaling and therapeutical relevance in glioma. Biochim Biophys Acta. 2014 Jun;1838(6):1619-27

pdf Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease Popular

Torres M, Price SL, Fiol-Deroque MA, Marcilla-Etxenike A, Ahyayauch H, Barceló-Coblijn G, Terés S, Katsouri L, Ordinas M, López DJ, Ibarguren M, Goñi FM, Busquets X, Vitorica J, Sastre M, Escribá PV. Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease. Biochim Biophys Acta. 2014 Jun;1838(6):1680-92

pdf Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets

Piotto S, Concilio S, Bianchino E, Iannelli P, López DJ, Terés S, Ibarguren M, Barceló-Coblijn G, Martin ML, Guardiola-Serrano F, Alonso-Sande M, Funari SS, Busquets X, Escribá PV. Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets. Biochim Biophys Acta. 2014 Jun;1838(6):1628-37

pdf Changes in membrane organization upon spontaneous insertion of 2-hydroxylated unsaturated fatty acids in the lipid bilayer Popular

Khmelinskaia A, Ibarguren M, de Almeida RF, López DJ, Paixão VA, Ahyayauch H, Goñi FM, Escribá PV. Changes in membrane organization upon spontaneous insertion of 2-hydroxylated unsaturated fatty acids in the lipid bilayer. Langmuir. 2014 Mar 4;30(8):2117-28

pdf The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health

Ibarguren M et al. The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health. Biochim Biophys Acta. 2014 Jun;1838(6):1518-28. doi: 10.1016

pdf Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives Popular

Ibarguren M, López DJ, Encinar JA, González-Ros JM, Busquets X, Escribá PV. Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives. Biochim Biophys Acta. 2013 Nov;1828(11):2553-63

pdf Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer’s disease following 2-hydroxy-DHA treatment Popular

Fiol-deRoque MA, Gutierrez-Lanza R, Terés S, Torres M, Barceló P, Rial RV, Verkhratsky A, Escribá PV, Busquets X, Rodríguez JJ. Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer’s disease following 2-hydroxy-DHA treatment. Biogerontology. 2013 Dec;14(6):763-75

pdf 2-Hydroxy Arachidonic Acid: A New Non-Steroidal Anti-Inflammatory Drug Popular

Lopez DH, Fiol-deRoque MA, Noguera-Salvà MA, Terés S, Campana F, Piotto S, Castro JA, Mohaibes RJ, Escribá PV, Busquets X. 2-Hydroxy Arachidonic Acid: A New Non-Steroidal Anti-Inflammatory Drug. PLoS One. 2013 Aug 27;8(8):e72052

pdf Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells

Martin ML et al. Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells. J Lipid Res. 2013;54(5):1457-65.

pdf The role of membrane fatty acid remodeling in the antitumor mechanism of action of 2-hydroxyoleic acid

Martín ML et al. The role of membrane fatty acid remodeling in the antitumor mechanism of action of 2-hydroxyoleic acid. Biochim. Biophys. Acta. Biomembranes. 2013;1828(5):1405-13

pdf 2OHOA Induces ER Stress and Autophagy in Various Human Glioma Cell Lines Popular

Marcilla-Etxenike A, Martín ML, Noguera-Salvà MA, García-Verdugo JM, Soriano-Navarro M, Dey I, Escribá PV, Busquets X. 2OHOA Induces ER Stress and Autophagy in Various Human Glioma Cell Lines. PLoS One. 2012;7(10):e48235

pdf 2-Hydroxyoleic acid induces ER stress and autophagy in various human glioma cell lines.

Marcilla-Etxenike A, et al. 2-Hydroxyoleic acid induces ER stress and autophagy in various human glioma cell lines. PLoS One. 2012;7(10):e48235. doi: 10.1371

pdf Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells Popular

Terés S, Lladó V, Higuera M, Barceló-Coblijn G, Martin ML, Noguera-Salvà MA, Marcilla-Etxenike A, García-Verdugo JM, Soriano-Navarro M, Saus C, Gómez-Pinedo U, Busquets X, Escribá PV. Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells. Autophagy. 2012 Oct;8(10):1542-4.

pdf Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells

Teres S et al. Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells. Autophagy. 2012 Oct;8(10):1542-4. doi: 10.4161

pdf 2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy Popular

Terés S, Lladó V, Higuera M, Barceló-Coblijn G, Martin ML, Noguera-Salvà MA, Marcilla-Etxenike A, García-Verdugo JM, Soriano-Navarro M, Saus C, Gómez-Pinedo U, Busquets X, Escribá PV. 2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8489-94

pdf Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells cells and in 2-hydroxyoleic acid therapy Popular

Barceló-Coblijn G, Martin ML, de Almeida RF, Noguera-Salvà MA, Marcilla-Etxenike A, Guardiola-Serrano F, Lüth A, Kleuser B, Halver JE, Escribá PV. Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells cells and in 2-hydroxyoleic acid therapy. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19569-74.

pdf Interactions of fatty acids with DEPE membranes: X-ray diffraction and molecular dynamics studies Popular

Cordomí A, Prades J, Frau J, Vögler O, Funari SS, Perez JJ, Escribá PV, Barceló F. Interactions of fatty acids with DEPE membranes: X-ray diffraction and molecular dynamics studies. J Lipid Res. 2010 May;51(5):1113-24.

pdf Minerval induces apoptosis in Jurkat and other cancer cells

Lladó V, et al. Minerval induces apoptosis in Jurkat and other cancer cells. J. Cell. Mol. Med. Vol 14, No 3, 2010 pp. 659-670

pdf 2OHOA induces apoptosis in Jurkat and other cancer cells Popular

Llado V, Gutierrez A, Martínez J, Casas J, Terés S, Higuera M, Galmés A, Saus C, Besalduch J, Busquets X, Escribá PV. 2OHOA induces apoptosis in Jurkat and other cancer cells. J Cell Mol Med. 2010 Mar;14(3):659-70

pdf Pivotal role of DHFR knockdown in the anticancer activity of 2-hydroxyoleic acid Popular

Lladó V, Terés S, Higuera M, Alvarez R, Noguera-Salva MA, Halver JE, Escribá PV, Busquets X. Pivotal role of DHFR knockdown in the anticancer activity of 2-hydroxyoleic acid. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13754-8.

pdf Membrane Lipid Therapy Popular

Encyclopedia of Cancer, M. Schwabb Ed. Membrane Lipid Therapy. Springer 2nd edition, 2008

pdf Oleic acid content is responsible for the reduction in blood pressure induced by olive oil Popular

Terés S, Barceló-Coblijn G, Benet M, Alvarez R, Bressani R, Halver JE, Escribá PV. Oleic acid content is responsible for the reduction in blood pressure induced by olive oil. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13811-6

pdf Membranes: a meeting point for lipids, proteins and therapies Popular

Escribá PV, González-Ros JM, Goñi FM, Kinnunen PK, Vigh L, Sánchez-Magraner L, Fernández AM, Busquets X, Horváth I, Barceló-Coblijn G. Membranes: a meeting point for lipids, proteins and therapies. J Cell Mol Med. 2008 Jun;12(3):829-75.

pdf Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats Popular

Vögler O, López-Bellan A, Alemany R, Tofé S, González M, Quevedo J, Pereg V, Barceló F, Escriba PV. Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats. Int J Obes (Lond). 2008 Mar;32(3):464-73

pdf Interaction of the C-Terminal Region of the Gg Protein with Model Membranes Popular

Barceló F, Prades J, Encinar JA, Funari SS, Vögler O, González-Ros JM, Escribá PV. Interaction of the C-Terminal Region of the Gg Protein with Model Membranes. Biophys J. 2007 Oct 1;93(7):2530-41

pdf Synthesis and mass spectroscopy kinetics of a novel ternary copper complex with cytotoxic activity

Barceló-Oliver M, García-Raso A, Terrón A, Molins E, Prieto MJ, Moreno V, Martínez J, Lladó V, López I, Gutiérrez A, Escribá PV. Synthesis and mass spectroscopy kinetics of a novel ternary copper complex with cytotoxic activity. J Inorg Biochem. 2007 Apr;101(4):649-59.

pdf Membrane Lipid Therapy: a new approach in molecular medicine Popular

Escriba PV. Membrane Lipid Therapy: a new approach in molecular medicine. Trends Mol Med. 2006 Jan;12(1):34-43

pdf The repression of E2F-1 is critical for the activity of Minerval against cancer

Martinez J, et al. The repression of E2F-1 is critical for the activity of Minerval against cancer. J Pharmacol Exp Ther. 2005 Oct;315(1):466-74

pdf Membrane structure modulation, protein kinase C alpha activation, and anticancer activity of Minerval Popular

Martínez J, Vögler O, Casas J, Barceló F, Alemany R, Prades J, Nagy T, Baamonde C, Kasprzyk PG, Terés S, Saus C, Escribá PV. Membrane structure modulation, protein kinase C alpha activation, and anticancer activity of Minerval. Mol Pharmacol. 2005 Feb;67(2):531-40

pdf The hypotensive drug 2-hydroxyoleic acid modifies the structural properties of model membranes

Barceló F, Prades J, Funari SS, Frau J, Alemany R, Escribá PV. The hypotensive drug 2-hydroxyoleic acid modifies the structural properties of model membranes. Mol Membr Biol. 2004 Jul-Aug;21(4):261-8.

pdf The Gbg dimer drives the interaction of heterotrimeric Gi proteins with nonlamellar membrane structure

Vögler O, Casas J, Capó D, Nagy T, Borchert G, Martorell G, Escribá PV. The Gbg dimer drives the interaction of heterotrimeric Gi proteins with nonlamellar membrane structure. J Biol Chem. 2004 Aug 27;279(35):36540-5.

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