LP204A1 in Inflammation


LP204A1 is a PUFA derivative that produces a remarkable anti-inflammatory effect in a LPS-challenged mouse model of inflammation acting through COX1 and COX2. Its efficacy is similar to that of steroid compounds, albeit its non-steroid structure suggests a lower toxicity, aspect that has been initially assessed in preliminary studies in zebra fish, flies and mice.

LP204A1 inhibits both COX-1 and COX-2, although it only induces proteaseome-associated degradation of COX-2, the inducible isoform involved in the inflammatory response.

A collaboration with an external research group (at the University of Leon, Spain) is currently ongoing to explore potential effect of LP2014A1 in an animal model of ischaemic lesion following brain stroke.

 


Relevant related documents:

::> Neuroprotective effect of 2-hydroxy arachidonic acid in a rat model of transient middle cerebral artery occlusion. Ugidos et al. Biochim Biophys Acta. 2017 Sep;1859(9 Pt B):1648-1656.

::> A role for lipids as agents to alleviate stroke damage: the neuroprotective effect of 2-hydroxy arachidonic acid. Ugidos et al. Neural Regen Res. 2017 Aug;12(8):1273-1275. doi: 10.4103

::> 2-Hydroxy Arachidonic Acid: A New Non-Steroidal Anti-Inflammatory Drug. Lopez et al. PLOS ONE, Aug. 2013

 


This research is supported by a grant of the Spanish Ministry of Economy and Competitivity (Desarrollo farmacéutico de lípidos de diseño para el tratamiento del ictus y patologías relacionadas (Metabolopatías), ICTUS, Ref: RTC-2015-4094-1)

Proyecto financiado por el Ministerio de Economía y Competitividad y cofinanciado por los Fondos Europeos de Desarrollo Regional (FEDER)

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