MLT

Membrane-Lipid Therapy (MLT) is an innovative scientific platform based on an expanding area of knowledge in today’s cell biology. The most commonly used rational approach in drug design involves isolating a protein to elucidate its structure and then the design of molecules (chemicals, antibodies…) that regulate its activity. In this approach the molecules designed to interact and inhibit the activity of such membrane-associated signal transduction proliferative proteins targets are synthetic fatty acids.

This novel therapeutic approach constitutes a "disruptive innovation" that can lead to the development of transformative new medicines with an exceptional safety/efficacy combination in serious pathologies with critical medical needs unmet, such as Oncology, Neurodegenerative or metabolic diseases.

The potential translation of significant clinical benefit to patients of MLT-based products is being evaluated in different studies, such as MIN-001-1203, the first clinical trial with 2-OHOA in patients with advanced solid tumours, including malignant glioma, which has already been completed with very promising results.


 

Relevant related documents:

::> Membrane-lipid therapy: A historical perspective of membrane-targeted therapies - From lipid bilayer structure to the pathophysiological regulation of cells. Escriba PV. Biochim Biophys Acta. 2017 Sep;1859(9 Pt B):1493-1506.

::> Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment. Escriba PV et al. Prog Lipid Res. 2015 May 9;59:38-53. Review.

::> The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health. Ibarguren et al. Biochim Biophys Acta. Jun. 2014

::> Membrane structure and function: relevance of lipid and protein structures in cellular physiology, pathology and therapy. Escriba PV et al. Biochim Biophys Acta. Jun. 2014

::> Changes in membrane organization upon spontaneous insertion of 2-hydroxylated unsaturated fatty acids in the lipid bilayer. Khmelinskaia A et al. Langmuir. 2014 Mar 4;30(8):2117-28

::> Membranes: a meeting point for lipids, proteins and therapiesEscriba PV et al. J. Cellular and Molecular Medicine, 2008

::> Membrane Lipid Therapy: a new approach in molecular medicineEscriba PV. Trends in Molecular Medicine, Jan. 2006

 

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